Pharmaceutical Methods
Publishing Quality Research & Reviews
Pharmaceutical Methods
Publishing Quality Research & Reviews
Author(s): Manoj Kumar Goyal*, Ashutosh Dubey and Lalit Kumar Yadav
Purpose: The aim of the present study was to develop a gastro retentive system of telmisartan to prolong its gastric residence time and bioavailability. Materials and Methods: Non aqueous solvent evaporation method was used to prepare floating microspheres of telmisartan with kollidon SR. Total five formulations were made with varying concentration of kollidon SR. Prepared floating microspheres were subjected to various evaluation parameters, such as particle size determination, SEM, percent yield, entrapment efficiency, bulk and tapped density, compressibility index, angle repose, In vitro floatability, FT-IR study and In vitro drug release. Results: All the formulations displayed good flow properties. In vitro dissolution studies in HCl buffer pH 1.2 were performed to assess the release profile of prepared floating microsphere formulations. All the five formulation displayed sustained release of drug. FT-IR spectra of formulation F3 exhibited all the peaks as similar to the FT-IR spectra of pure drug, rejecting any doubts about the compatibility between drug and the excipients. Conclusion: We can conclude that kollidon SR can be successfully used to prepare floating microspheres of telmisartan to increase its gastric residence time and bioavailability.
