Pharmaceutical Methods
Publishing Quality Research & Reviews
Pharmaceutical Methods
Publishing Quality Research & Reviews
Author(s): Akhil Nagar*, Pritam Jain*, Santosh Bodkhe, Kapil Agrawal and Urmila Salunke
Objective: Pregabalin (PGB) is an antiepileptic drug, named (S)-3-(aminomethyl)-5-methyl hexanoic acid. Since the discovery, PGB has remained the main representative drug from the antiepileptic category, due to its unique mode of action which concerns the treatment of painful diabetic neuropathy postherpetic neuralgia by lagging down the impulses in the brain which causes seizures.
Chemically, PGB shows amphoteric (zwitterionic) properties and the presence of a chiral center reflects the comparatively high biological activity of one of its isomers. Analytically, the ring closure and ring-opening of PGB depend on the solubility and the method or instrument adopted. The analytical techniques in pharmaceuticals are used for analysis and drug monitoring remains important in perceiving factors like bioavailability, bioequivalence, and therapeutic monitoring.Due to all mentioned features, it becomes necessary to compile the various analytical methods that have been reported in the literature for its analysis. The present critical review assesses the compilation of relevant articles that have already been published in recent ten years, describing analytical methods like UV, HPLC (single and combined dosage form), HPTLC, LC-MS/MS, and GC/ MS method for the same.
Conclusion: The present comprehensive review disclosed a summary of pharmacokinetics-dynamics, pharmaceutical preparations, and analytical methods of bulk drug and biological matrices since the time of discovery.
