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Simple and Economical UV Spectrophotometric Area under Curve Method for Estimation of Eletriptan Hydro bromide

Submitted by webadmin on Tue, 08/29/2017 - 13:07
Pharmaceutical Methods,2018,9,1,30-33.
Published:September 2017
Type:Original Article

Simple and Economical UV Spectrophotometric Area under Curve Method for Estimation of Eletriptan Hydro bromide

Mahesh Mukund Deshpande*1, Veena Sanjay Kasture2, Mahalaxmi Mohan3

1Research Scholar of Jawaharlal Nehru Technological University, Hyderabad, Telangana, India, Amrutvahini College of Pharmacy, Sangamner, Dist. Ahmadnagar, M.S. India, Savitribai Phule Pune University, Pune, Maharashtra, INDIA.

2Directore, Pinnacle Biomedical Reasearch Institute, Bhopal, Madhya Pradesh, INDIA.

3Head of Department, MGV’s Pharmacy College, Nashik, Maharashtra, INDIA.

Abstract:

Objective: Simple and economical area under curve method was developed and validated for the estimation of Eletriptan Hydrobromide. Method: The solvent implemented for estimation of Eletriptan Hydrobromide was water. The λmax was found to be 221 nm.The area under curve of UV spectrum between 216 to 226 nm. The method is validated according to ICH guideline Q2(R1). Results: The linearity range of Eletriptan HBr was found to be 5-25 μg/ml. The correlation coefficient was found to be 0.999. The values of %RSD for inter and intra-day precisions were within the acceptable limit. LOD and LOQ were found to be 5.77 μg/ml and 1.90 μg/ml respectively. % Recovery of Eletriptan HBr was 99.66 to 99.95.The values of ruggedness shows the method is rugged. Conclusion: The developed method can be implemented for routine analysis of Eletriptan HBr in bulk as well as formulation as per ICH Q2 (R1) guidelines.

Figure 1: Structure of EletriptanHydrobromide.