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Synthesis and Evaluation of Antipsychotic Compounds from Lupeol

Submitted by webadmin on Wed, 03/15/2017 - 13:42
Pharmaceutical Methods,2017,8,2,81-86.
Published:March 2017
Type:Original Article

Synthesis and Evaluation of Antipsychotic Compounds from Lupeol

Ankita Wal1*, Radhey Shyam Srivastava2 and Awani Kumar Rai1, Pranay Wal1, Ruchi Tiwari1

1Department of Pharmacy, Pranveer Singh Institute of Technology, Bhauti Road, Kanpur, Uttar Pradesh, INDIA.

2Institute of Pharmacy Indian institute of Technology ( Banaras Hindu University ) Varanasi, INDIA

Abstract:

Aim: The current study was designed to evaluate the antipsychotic potential of lupeol and their semisynthetic derivatives to get a new and potent antipsychotic agent. Methodology: Lupeol was isolated from bark of crateava nurvala. the current study was designed to evaluate the antipsychotic potential of lupeol and its semisynthetic derivatives. C. Nurvala stem bark was extracted by cold maceration with 95% ethanol and concentrated through rotary vacuum evaporator under reduced pressure. The concentrated ethanolic extract was defatted with petroleum ether and fractionated with chloroform successively. Lupeol derivatives were prepared through a three step reaction with different amines, aliphatic and aromatic moieties. A series of derivatives of lupeol were assayed for antipshychotic activity in actophotometer and compulsive behaviour (Stereotypy) in Plus Maze Model in rats. Few derivatives of lupeol showed more potent activity as compared to the basic molecule, lupeol. Results: The results of the present study clearly indicated that the derivatives and lupeol isolated from C. Nurvala and synthetic lupeol analogs possess significant antipsychotic activity. Conclusion: Lupeol skeleton deserves further investigation for the development of more potent and non-toxic new antipshychotic agents for therapeutic applications.

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Locomotor activity of lupeol derivatives and standard drug