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UV-visible spectrophotometric simultaneous estimation of paracetamol and nabumetone by AUC method in combined tablet dosage form

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Pharmaceutical Methods,2012,3,1,40-43.
Published:June 2012
Type:Original Article

UV-visible spectrophotometric simultaneous estimation of paracetamol and nabumetone by AUC method in combined tablet dosage form

Ambadas R. Rote, Prasanna A. Kumbhoje, Rajendra S. Bhambar

Department of Pharmaceutical Chemistry, MGV’s Pharmacy College, (Pune University), Panchavati, Mumbai Agra Road, Nashik, India

Abstract:

Introduction: The present study deals with development and validation of a simple, rapid, sensitive and economic area under curve method for simultaneous estimation of paracetamol and nabumetone in bulk and tablet dosage form. Materials and Method: Area under curve method includes determination of area of paracetamol and nabumetone at absorption maxima, which for paracetamol was 248.8 ± 10 nm and for nabumetone was 269.2 ± 10 nm. Beer’s law was obeyed in the concentration range of 5–25 μg/mL for both paracetamol and nabumetone. Correlation coefficient was found to be 0.9983 and 0.9993 for paracetamol and nabumetone, respectively for area under curve method. Results: The analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for the proposed method. The percentage recovery was found to be 101.67–102.43% for paracetamol and 96.69–98.49% for nabumetone. Conclusion: The proposed AUC method used for the simultaneous estimation of PARA and NAB in bulk and tablet dosage formrespectively.