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Assay of tianeptine sodium in bulk and its marketed formulations by extraction visible spectrophotometry

Submitted by admin on Tue, 10/25/2016 - 12:18
Pharamaceutical Methods,2013,4,1,30-32.
Type:Short Communication

Assay of tianeptine sodium in bulk and its marketed formulations by extraction visible spectrophotometry

Abstract:

A simple, sensitive and cost effective extraction visible spectrophotometric method without using buffer solution has been described for the determination of tianeptine in pure and tablet dosage form. The method is based on the formation of colored ion-association complex between the basic nitrogen of the drug and acidic dye Tropaelin OOO (orange dye II) in the presence of acid medium which is extractable into chloroform with an absorption maximum of 489 nm. The optimum operating conditions necessary for the assaying the drug is established. The Beer's law obeyed in the concentration range of 4–20 μg/ml with correlation coefficient r2 = 0.998. The proposed method is applied to commercial available STABLON tablets and the results are statistically compared with those obtained by the reported UV reference method and validated using recovery studies. Keywords: Tri cyclic antidepressant; Estimation; Ion-association complex; Statistical analysis; TPOOO.

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