An International, Peer-Reviewed, Open Access Multidisciplinary Pharmacy Journal

Simultaneous Derivative Spectrophotometric Determination of Lornoxicam and Paracetamol in Tablet Dosage Forms

Submitted by webadmin on Tue, 10/18/2016 - 17:34
Pharmaceutical Methods,2015,6,3,126-129.
Published:July 2015
Type:Original Article

Simultaneous Derivative Spectrophotometric Determination of Lornoxicam and Paracetamol in Tablet Dosage Forms

Bharampuram Akhil, Routhu Krishna Chaitanya, Bukkapatnam Venkatesh, and Mukthinuthalapati Mathrusri Annapurna*

Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, INDIA

Abstract:

A simple, rapid, precise and accurate derivative spectrophotometric method has been developed for the determination of Lornoxicam and Paracetamol in combined dosage forms (Tablets). The zero crossing point of Paracetamol (247.42 nm) has been selected for the quantification of Lornoxicam whereas the zero crossing point of Lornoxicam (233.28 nm) has been selected for the quantification of Paracetamol from the first order derivative spectrum observed in borate buffer. The method obeys Beer-Lambert’s law over the concentration range 5-50 μg/ml for Lornoxicam and 5-60 μg/ml for Paracetamol. The proposed method was validated and can be used for the analysis of tablet dosage forms containing Lornoxicam and Paracetamol.

Overlay first derivative spectrum of Lornoxicam (—) over Paracetamol (—)