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Effect of Different Diffusion Membranes on the Diffusion Rate of Niacinamide and Diclofenac Sodium From Topical Formulations

Submitted by webadmin on Tue, 10/18/2016 - 15:01
Pharmaceutical Methods,2016,7,2,94-98.
Published:July 2016
Type:Original Article

Effect of Different Diffusion Membranes on the Diffusion Rate of Niacinamide and Diclofenac Sodium From Topical Formulations

Ramesh Suriyanarayanan*, Hosakote Gurumallappa Shivakumar, Nagaraja Shivanandappa

Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri ShivarathreeshwaraNagara, Mysuru 570015, INDIA.

Abstract:

The aim of the study was to correlate diffusivity of Niacinamide from a cream formulation and Diclofenac sodium from a gel formulation. Evaluation is done by in vitro drug release through Franz diffusion cell and different diffusion membranes. The membranes used for the study were Polytetrafluoroethylene (PTFE), Polyvinylidene fluoride (PVDF) and Dialysis membranes. Phosphate buffer pH 5.5 was the receptor medium. Studies showed significant variations in the diffusion rate of niacinamide and Diclofenac sodium across different membranes. The percentage of Niacinamide diffused from niacinamide cream after 120 min was found to be PTFE (1.5%), PVDF (54.15%) and Dialysis membranes (21.6%). The percentage of diclofenac sodium diffused from diclofenac gel after 180 min was found to be PTFE (2.42%), PVDF (14.42%) and Dialysis membranes (9.8%). From the study it was concluded that membranes having different characteristic property shows different diffusivity. Therefore interpretation of in vitro diffusion data to correlate with in vivo dermal penetration need further in-depth study.

Effect of diffusion membranes on penetration of diclofenac sodium gel