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Formulation and Evaluation of Orodispersible Tablets of Granisetron Hydrochloride Using Agar as Natural Super disintegrants

Submitted by webadmin on Tue, 10/18/2016 - 12:10
Pharmaceutical Methods,2016,7,1,17-22.
Published:January 2016
Type:Original Article

Formulation and Evaluation of Orodispersible Tablets of Granisetron Hydrochloride Using Agar as Natural Super disintegrants

Chinmaya Keshari Sahoo1*, Nalini Kanta Sahoo2, Madhusmita Sahu2, Alok Kumar Moharana3, Deepak Kumar Sarangi3

1Department of Pharmaceutics, Osmania University College of Technology, Osmania University, Hyderabad, A.P. INDIA.

2Department of Pharmaceutical Analysis and Quality assurance, MNR College of Pharmacy, Fasalwadi, Sangareddy, Medak, Telangana, INDIA.

3Department of Pharmaceutical Analysis and Quality assurance, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy Dist-500388, INDIA.

Abstract:

The main aim of the study was to develop orodispersible tablets of Granisetron hydrochloride a selective 5-HT3 receptor antagonist (an antivomiting agent) for improving patient compliance, especially those of paediatric and geriatric categories with difficulties in swallowing. In the wet granulation method orodispersible (ORD) tablets were prepared using natural super disintegrants Agar agar. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, in vitro dispersion time, drug content and in vitro dissolution studies. The tablet formulation batch F4 was considered as the overall best formulation (with an in vitro drug release study of 99.09%). Short term stability studies (at 40 ± 2ºC/75 ± 5% RH) on the best formulation indicated that there no significant changes in drug content. From the FTIR study indicated that there are no drug excipient interactions.

FTIR spectrum of Granisetron HCl pure drug